Small molecule high throughput screen using AstraZeneca facilities

What the assessor looks for

• is of excellent quality and importance within or beyond the field
• has the potential to advance current understanding, or generate new knowledge, thinking or discovery within or beyond the field
• is timely given current trends, context, and needs
• describe the unmet need for new therapeutic approaches to the disease of interest
• describe how the target is involved in the pathology or aetiology of the disease of interest
• describe how manipulation of the target could produce disease modifying effects
• target type, for example soluble cytokine, cell surface protein
• mechanism of action, for example agonist, antagonist
• proposed therapeutic use, for example disease, subpopulation
• route of administration and dosing frequency, for example IV or sub-cutaneous with daily or weekly dosing frequency, which are acute or chronic

A filled dot only means your answer mentions that ground. It is not a judgement of how well.

What the assessor looks for

• is effective and appropriate to achieve your objectives
• is feasible, and comprehensively identifies any risks to delivery and how they will be managed
• uses a clearly written and transparent methodology (if applicable)
• summarises the previous work and describes how this will be built upon and progressed (if applicable)
• will maximise translation of outputs into outcomes and impacts
• describes how your, and if applicable your team’s, research environment (in terms of the place and relevance to the project) will contribute to the success of the work
• demonstrate access to the appropriate services, facilities, infrastructure, or equipment to deliver the elements of the project to be conducted outside the AstraZeneca facilities
• provide a project plan for the assay cascade beyond the initial HTS run in the form of an embedded schematic
• describe your approach to ethical and regulatory approvals and their status. Consider the MRC guidance on ethics and approvals
• explain and justify any use of human tissues or biological samples, including the type of material to be used, quantity required, and its source
• cells, including GMO and hazard group
• reduction or removal of any high-risk reagents

A filled dot only means your answer mentions that ground. It is not a judgement of how well.

What the assessor looks for

• £150,000, 100% exception costs relating to staff and consumables at AstraZeneca (justification is not required for fixed costs)
• £20,000, 100% exception costs related to AstraZeneca optimising the assay, looking at alternate readouts and running a feasibility panel (justification is not required for fixed costs)
• up to £100,000 full economic cost (£80,000 MRC contribution) to costs incurred at the research organisation for follow up assays (this figure to also include cost of sending a researcher to AstraZeneca for up to three months)
• project staff
• significant travel for field work or collaboration (but not regular travel between collaborating organisations or to conferences)
• any equipment that will cost more than £25,000
• any consumables beyond typical requirements, or that are required in exceptional quantities
• all facilities and infrastructure costs
• all resources that have been costed as ‘Exceptions’
• are comprehensive, appropriate, and justified
• represent the optimal use of resources to achieve the intended outcomes
• maximise potential outcomes and impacts

A filled dot only means your answer mentions that ground. It is not a judgement of how well.

What the assessor looks for

• the relevant experience ( appropriate to career stage ) to deliver the proposed work
• the right balance of skills and expertise to cover the proposed work
• the appropriate leadership and management skills to deliver the work and your approach to develop others
• contributed to developing a positive research environment and wider community
• contributions to the generation of new ideas, tools, methodologies, or knowledge
• the development of others and maintenance of effective working relationships
• contributions to the wider research and innovation community
• contributions to broader research or innovation users and audiences and towards wider societal benefit

A filled dot only means your answer mentions that ground. It is not a judgement of how well.

What the assessor looks for

• name of facility, copied and pasted from the facility information list (DOCX, 42KB)
• proposed usage or costs, or costs per unit where indicated on the facility information list
• confirmation you have their agreement where required

A filled dot only means your answer mentions that ground. It is not a judgement of how well.

What the assessor looks for

• population cohorts, longitudinal studies, genetic, omics and imaging data, biobanks, and other collections that are potentially a rich resource for the wider research community: maximum of 1,500 words
• all other research, less complex, the plan may be as short as 500 words

A filled dot only means your answer mentions that ground. It is not a judgement of how well.

What the assessor looks for

• the relevant ethical and RRI considerations, including both the research or topic area itself and the design and delivery of the project
• the wider implications of the proposed work, and how you will maximise the positive societal, environmental, and economic benefits arising from the project, while minimising unintended negative impacts, such as research misuse or accidental harm
• how you will manage these considerations throughout the lifecycle of the project

A filled dot only means your answer mentions that ground. It is not a judgement of how well.